#ifndef STIM_NETWORK_H #define STIM_NETWORK_H #include #include #include #include #include #include #include #include #include #include #include "cylinder.h" #include #include #include //********************help function******************** // gaussian_function CUDA_CALLABLE float gaussianFunction(float x, float std = 25) { return exp(-x / (2 * std*std)); } // std default sigma value is 25 // compute metric in parallel #ifdef __CUDACC__ template __global__ void find_metric_parallel(T* M, size_t n, T* D, float sigma){ size_t x = blockDim.x * blockIdx.x + threadIdx.x; if(x >= n) return; M[x] = 1.0f - gaussianFunction(D[x], sigma); } //find the corresponding edge index from array index __global__ void find_edge_index_parallel(size_t* I, size_t n, unsigned* R, size_t* E, size_t ne){ size_t x = blockDim.x * blockIdx.x + threadIdx.x; if(x >= n) return; unsigned i = 0; size_t N = 0; for(unsigned e = 0; e < ne; e++){ N += E[e]; if(I[x] < N){ R[x] = i; break; } i++; } } #endif //hard-coded factor int threshold_fac; namespace stim{ /** This is the a class that interfaces with gl_spider in order to store the currently * segmented network. The following data is stored and can be extracted: * 1)Network geometry and centerline. * 2)Network connectivity (a graph of nodes and edges), reconstructed using kdtree. */ template class network{ ///Each edge is a fiber with two nodes. ///Each node is an in index to the endpoint of the fiber in the nodes array. class edge : public cylinder { public: unsigned int v[2]; //unique id's designating the starting and ending // default constructor edge() : cylinder() { v[1] = (unsigned)(-1); v[0] = (unsigned)(-1); } /// Constructor - creates an edge from a list of points by calling the stim::fiber constructor /* ///@param v0, the starting index. ///@param v1, the ending index. ///@param sz, the number of point in the fiber. edge(unsigned int v0, unsigned int v1, unsigned int sz) : cylinder( { } */ edge(std::vector > p, std::vector s) : cylinder(p,s) { } ///@param p is an array of positions in space edge(stim::centerline p) : cylinder(p){} /// Copy constructor creates an edge from a cylinder edge(stim::cylinder f) : cylinder(f) {} /// Resamples an edge by calling the fiber resampling function edge resample(T spacing){ edge e(cylinder::resample(spacing)); //call the fiber->edge constructor e.v[0] = v[0]; //copy the vertex data e.v[1] = v[1]; return e; //return the new edge } /// Output the edge information as a string std::string str(){ std::stringstream ss; ss<<"("<::size()<<")\tl = "<length()<<"\t"< split(unsigned int idx){ std::vector< stim::cylinder > C; C.resize(2); C = (*this).cylinder::split(idx); std::vector E(C.size()); for(unsigned e = 0; e < E.size(); e++){ E[e] = C[e]; } return E; } /// operator for writing the edge information into a binary .nwt file. friend std::ofstream& operator<<(std::ofstream& out, const edge& e) { out.write(reinterpret_cast(&e.v[0]), sizeof(unsigned int)); ///write the starting point. out.write(reinterpret_cast(&e.v[1]), sizeof(unsigned int)); ///write the ending point. unsigned int sz = e.size(); ///write the number of point in the edge. out.write(reinterpret_cast(&sz), sizeof(unsigned int)); for(int i = 0; i < sz; i++) ///write each point { stim::vec3 point = e[i]; out.write(reinterpret_cast(&point[0]), 3*sizeof(T)); // for(int j = 0; j < nmags(); j++) //future code for multiple mags // { out.write(reinterpret_cast(&e.R[i]), sizeof(T)); ///write the radius //std::cout << point.str() << " " << e.R[i] << std::endl; // } } return out; //return stream } /// operator for reading an edge from a binary .nwt file. friend std::ifstream& operator>>(std::ifstream& in, edge& e) { unsigned int v0, v1, sz; in.read(reinterpret_cast(&v0), sizeof(unsigned int)); //read the staring point. in.read(reinterpret_cast(&v1), sizeof(unsigned int)); //read the ending point in.read(reinterpret_cast(&sz), sizeof(unsigned int)); //read the number of points in the edge // stim::centerline temp = stim::centerline(sz); //allocate the new edge // e = edge(temp); std::vector > p(sz); std::vector r(sz); for(int i = 0; i < sz; i++) //set the points and radii to the newly read values { stim::vec3 point; in.read(reinterpret_cast(&point[0]), 3*sizeof(T)); p[i] = point; T mag; // for(int j = 0; j < nmags(); j++) ///future code for mags // { in.read(reinterpret_cast(&mag), sizeof(T)); r[i] = mag; //std::cout << point.str() << " " << mag << std::endl; // } } e = edge(p,r); e.v[0] = v0; e.v[1] = v1; return in; } }; ///Node class that stores the physical position of the node as well as the edges it is connected to (edges that connect to it), As well as any additional data necessary. class vertex : public stim::vec3 { public: //std::vector edges; //indices of edges connected to this node. std::vector e[2]; //indices of edges going out (e[0]) and coming in (e[1]) //stim::vec3 p; //position of this node in physical space. //default constructor vertex() : stim::vec3() { } //constructor takes a stim::vec vertex(stim::vec3 p) : stim::vec3(p){} /// Output the vertex information as a string std::string str(){ std::stringstream ss; ss<<"\t(x, y, z) = "<::str(); if(e[0].size() > 0){ ss<<"\t> "; for(unsigned int o = 0; o < e[0].size(); o++) ss< 0){ ss<<"\t< "; for(unsigned int i = 0; i < e[1].size(); i++) ss<(&v.ptr[0]), 3*sizeof(T)); ///write physical vertex location out.write(reinterpret_cast(&s0), sizeof(unsigned int)); ///write the number of "outgoing edges" out.write(reinterpret_cast(&s1), sizeof(unsigned int)); ///write the number of "incoming edges" if (s0 != 0) out.write(reinterpret_cast(&v.e[0][0]), sizeof(unsigned int)*v.e[0].size()); ///write the "outgoing edges" if (s1 != 0) out.write(reinterpret_cast(&v.e[1][0]), sizeof(unsigned int)*v.e[1].size()); ///write the "incoming edges" return out; } ///operator for reading the vector out of the stream; friend std::ifstream& operator>>(std::ifstream& in, vertex& v) { in.read(reinterpret_cast(&v[0]), 3*sizeof(T)); ///read the physical position unsigned int s[2]; in.read(reinterpret_cast(&s[0]), 2*sizeof(unsigned int)); ///read the sizes of incoming and outgoing edge arrays std::vector one(s[0]); std::vector two(s[1]); v.e[0] = one; v.e[1] = two; if (one.size() != 0) in.read(reinterpret_cast(&v.e[0][0]), s[0] * sizeof(unsigned int)); ///read the arrays of "outgoing edges" if (two.size() != 0) in.read(reinterpret_cast(&v.e[1][0]), s[1] * sizeof(unsigned int)); ///read the arrays of "incoming edges" return in; } }; protected: std::vector E; //list of edges std::vector V; //list of vertices. public: ///default constructor network() { } ///constructor with a file to load. network(std::string fileLocation) { load_obj(fileLocation); } ///Returns the number of edges in the network. unsigned int edges(){ return E.size(); } ///Returns the number of nodes in the network. unsigned int vertices(){ return V.size(); } ///Returns the radius at specific point in the edge T get_r(unsigned e, unsigned i) { return E[e].r(i); } ///Returns the average radius of specific edge T get_average_r(unsigned e) { T result = 0.0; unsigned n = E[e].size(); for (unsigned p = 0; p < n; p++) result += E[e].r(p); return (T)result / n; } ///Returns the length of current edge T get_l(unsigned e) { return E[e].length(); } ///Returns the start vertex of current edge size_t get_start_vertex(unsigned e) { return E[e].v[0]; } ///Returns the end vertex of current edge size_t get_end_vertex(unsigned e) { return E[e].v[1]; } ///Returns one vertex stim::vec3 get_vertex(unsigned i) { return V[i]; } ///Returns the boundary vertices' indices std::vector get_boundary_vertex() { std::vector result; for (unsigned v = 0; v < V.size(); v++) { if (V[v].e[0].size() + V[v].e[1].size() == 1) { // boundary vertex result.push_back(v); } } return result; } ///Set radius void set_r(unsigned e, std::vector radius) { E[e].cylinder::copy_r(radius); } void set_r(unsigned e, T radius) { for (size_t i = 0; i < E[e].size(); i++) E[e].cylinder::set_r(i, radius); } //scale the network by some constant value // I don't think these work?????? /*std::vector operator*(T s){ for (unsigned i=0; i< vertices; i ++ ){ V[i] = V[i] * s; } return V; } std::vector operator*(vec s){ for (unsigned i=0; i< vertices; i ++ ){ for (unsigned dim = 0 ; dim< 3; dim ++){ V[i][dim] = V[i][dim] * s[dim]; } } return V; }*/ // Returns an average of branching index in the network double BranchingIndex(){ double B=0; for(unsigned v=0; v < V.size(); v ++){ B += ((V[v].e[0].size()) + (V[v].e[1].size())); } B = B / V.size(); return B; } // Returns number of branch points in thenetwork unsigned int BranchP(){ unsigned int B=0; unsigned int c; for(unsigned v=0; v < V.size(); v ++){ c = ((V[v].e[0].size()) + (V[v].e[1].size())); if (c > 2){ B += 1;} } return B; } // Returns number of end points (tips) in thenetwork unsigned int EndP(){ unsigned int B=0; unsigned int c; for(unsigned v=0; v < V.size(); v ++){ c = ((V[v].e[0].size()) + (V[v].e[1].size())); if (c == 1){ B += 1;} } return B; } //// Returns a dictionary with the key as the vertex //std::map,unsigned int> DegreeDict(){ // std::map,unsigned int> dd; // unsigned int c = 0; // for(unsigned v=0; v < V.size(); v ++){ // c = ((V[v].e[0].size()) + (V[v].e[1].size())); // dd[V[v]] = c; // } // return dd; //} //// Return number of branching stems //unsigned int Stems(){ // unsigned int s = 0; // std::map,unsigned int> dd; // dd = DegreeDict(); // //for(unsigned v=0; v < V.size(); v ++){ // // V[v].e[0]. // return s; //} //Calculate Metrics--------------------------------------------------- // Returns an average of fiber/edge lengths in the network double Lengths(){ stim::vec L; double sumLength = 0; for(unsigned e = 0; e < E.size(); e++){ //for each edge in the network L.push_back(E[e].length()); //append the edge length sumLength = sumLength + E[e].length(); } double avg = sumLength / E.size(); return avg; } // Returns an average of tortuosities in the network double Tortuosities(){ stim::vec t; stim::vec id1, id2; // starting and ending vertices of the edge double distance;double tortuosity;double sumTortuosity = 0; for(unsigned e = 0; e < E.size(); e++){ //for each edge in the network id1 = E[e][0]; //get the edge starting point id2 = E[e][E[e].size() - 1]; //get the edge ending point distance = (id1 - id2).len(); //displacement between the starting and ending points if(distance > 0){ tortuosity = E[e].length()/ distance ; // tortuoisty = edge length / edge displacement } else{ tortuosity = 0;} t.push_back(tortuosity); sumTortuosity += tortuosity; } double avg = sumTortuosity / E.size(); return avg; } // Returns average contraction of the network double Contractions(){ stim::vec t; stim::vec id1, id2; // starting and ending vertices of the edge double distance;double contraction;double sumContraction = 0; for(unsigned e = 0; e < E.size(); e++){ //for each edge in the network id1 = E[e][0]; //get the edge starting point id2 = E[e][E[e].size() - 1]; //get the edge ending point distance = (id1 - id2).len(); //displacement between the starting and ending points contraction = distance / E[e].length(); // tortuoisty = edge length / edge displacement t.push_back(contraction); sumContraction += contraction; } double avg = sumContraction / E.size(); return avg; } // returns average fractal dimension of the branches of the network double FractalDimensions(){ stim::vec t; stim::vec id1, id2; // starting and ending vertices of the edge double distance;double fract;double sumFractDim = 0; for(unsigned e = 0; e < E.size(); e++){ //for each edge in the network id1 = E[e][0]; //get the edge starting point id2 = E[e][E[e].size() - 1]; //get the edge ending point distance = (id1 - id2).len(); //displacement between the starting and ending points fract = std::log(distance) / std::log(E[e].length()); // tortuoisty = edge length / edge displacement t.push_back(sumFractDim); sumFractDim += fract; } double avg = sumFractDim / E.size(); return avg; } //returns a cylinder represented a given fiber (based on edge index) stim::cylinder get_cylinder(unsigned e){ return E[e]; //return the specified edge (casting it to a fiber) } /// subdivide current network void subdivision() { std::vector ori_index; // original index std::vector new_index; // new index std::vector nE; // new edge std::vector nV; // new vector unsigned id = 0; unsigned num_edge = (*this).E.size(); for (unsigned i = 0; i < num_edge; i++) { if (E[i].size() == 2) { // if current edge can't be subdivided stim::centerline line(2); for (unsigned k = 0; k < 2; k++) line[k] = E[i][k]; line.update(); edge new_edge(line); vertex new_vertex = new_edge[0]; id = E[i].v[0]; auto position = std::find(ori_index.begin(), ori_index.end(), id); if (position == ori_index.end()) { // new vertex ori_index.push_back(id); new_index.push_back(nV.size()); new_vertex.e[0].push_back(nE.size()); new_edge.v[0] = nV.size(); nV.push_back(new_vertex); // push back vertex as a new vertex } else { // existing vertex int k = std::distance(ori_index.begin(), position); new_edge.v[0] = new_index[k]; nV[new_index[k]].e[0].push_back(nE.size()); } new_vertex = new_edge[1]; id = E[i].v[1]; position = std::find(ori_index.begin(), ori_index.end(), id); if (position == ori_index.end()) { // new vertex ori_index.push_back(id); new_index.push_back(nV.size()); new_vertex.e[1].push_back(nE.size()); new_edge.v[1] = nV.size(); nV.push_back(new_vertex); // push back vertex as a new vertex } else { // existing vertex int k = std::distance(ori_index.begin(), position); new_edge.v[1] = new_index[k]; nV[new_index[k]].e[1].push_back(nE.size()); } nE.push_back(new_edge); nE[nE.size() - 1].cylinder::set_r(0, E[i].cylinder::r(0)); nE[nE.size() - 1].cylinder::set_r(1, E[i].cylinder::r(1)); } else { // subdivide current edge for (unsigned j = 0; j < E[i].size() - 1; j++) { stim::centerline line(2); for (unsigned k = 0; k < 2; k++) line[k] = E[i][j + k]; line.update(); edge new_edge(line); if (j == 0) { // edge contains original starting point vertex new_vertex = new_edge[0]; id = E[i].v[0]; auto position = std::find(ori_index.begin(), ori_index.end(), id); if (position == ori_index.end()) { // new vertex ori_index.push_back(id); new_index.push_back(nV.size()); new_vertex.e[0].push_back(nE.size()); new_edge.v[0] = nV.size(); nV.push_back(new_vertex); // push back vertex as a new vertex } else { // existing vertex int k = std::distance(ori_index.begin(), position); new_edge.v[0] = new_index[k]; nV[new_index[k]].e[0].push_back(nE.size()); } new_vertex = new_edge[1]; new_vertex.e[1].push_back(nE.size()); new_edge.v[1] = nV.size(); nV.push_back(new_vertex); // push back internal point as a new vertex nE.push_back(new_edge); } else if (j == E[i].size() - 2) { // edge contains original ending point vertex new_vertex = new_edge[1]; nV[nV.size() - 1].e[0].push_back(nE.size()); new_edge.v[0] = nV.size() - 1; id = E[i].v[1]; auto position = std::find(ori_index.begin(), ori_index.end(), id); if (position == ori_index.end()) { // new vertex ori_index.push_back(id); new_index.push_back(nV.size()); new_vertex.e[1].push_back(nE.size()); new_edge.v[1] = nV.size(); nV.push_back(new_vertex); // push back vertex as a new vertex } else { // existing vertex int k = std::distance(ori_index.begin(), position); new_edge.v[1] = new_index[k]; nV[new_index[k]].e[1].push_back(nE.size()); } nE.push_back(new_edge); } else { vertex new_vertex = new_edge[1]; nV[nV.size() - 1].e[0].push_back(nE.size()); new_vertex.e[1].push_back(nE.size()); new_edge.v[0] = nV.size() - 1; new_edge.v[1] = nV.size(); nV.push_back(new_vertex); nE.push_back(new_edge); } // get radii nE[nE.size() - 1].cylinder::set_r(0, E[i].cylinder::r(j)); nE[nE.size() - 1].cylinder::set_r(1, E[i].cylinder::r(j + 1)); } } } (*this).E = nE; (*this).V = nV; } //load a network from an OBJ file void load_obj(std::string filename){ stim::obj O; //create an OBJ object O.load(filename); //load the OBJ file as an object std::vector id2vert; //this list stores the OBJ vertex ID associated with each network vertex unsigned i[2]; //temporary, IDs associated with the first and last points in an OBJ line //for each line in the OBJ object for(unsigned int l = 1; l <= O.numL(); l++){ std::vector< stim::vec > c; //allocate an array of points for the vessel centerline O.getLine(l, c); //get the fiber centerline stim::centerline c3(c.size()); for(size_t j = 0; j < c.size(); j++) c3[j] = c[j]; c3.update(); // edge new_edge = c3; ///This is dangerous. edge new_edge(c3); //create an edge from the given centerline unsigned int I = new_edge.size(); //calculate the number of points on the centerline //get the first and last vertex IDs for the line std::vector< unsigned > id; //create an array to store the centerline point IDs O.getLinei(l, id); //get the list of point IDs for the line i[0] = id.front(); //get the OBJ ID for the first element of the line i[1] = id.back(); //get the OBJ ID for the last element of the line std::vector::iterator it; //create an iterator for searching the id2vert array unsigned it_idx; //create an integer for the id2vert entry index //find out if the nodes for this fiber have already been created it = find(id2vert.begin(), id2vert.end(), i[0]); //look for the first node if(it == id2vert.end()){ //if i[0] hasn't already been used vertex new_vertex = new_edge[0]; //create a new vertex, assign it a position bool flag = false; unsigned j = 0; for (; j < V.size(); j++) { // check whether current vertex is already exist if (new_vertex == V[j]) { flag = true; break; } } if (!flag) { // unique one new_vertex.e[0].push_back(E.size()); //add the current edge as outgoing new_edge.v[0] = V.size(); //add the new edge to the edge V.push_back(new_vertex); //add the new vertex to the vertex list id2vert.push_back(i[0]); //add the ID to the ID->vertex conversion list } else { V[j].e[0].push_back(E.size()); new_edge.v[0] = j; } } else{ //if the vertex already exists it_idx = std::distance(id2vert.begin(), it); V[it_idx].e[0].push_back(E.size()); //add the current edge as outgoing new_edge.v[0] = it_idx; } it = find(id2vert.begin(), id2vert.end(), i[1]); //look for the second ID if(it == id2vert.end()){ //if i[1] hasn't already been used vertex new_vertex = new_edge[I-1]; //create a new vertex, assign it a position bool flag = false; unsigned j = 0; for (; j < V.size(); j++) { // check whether current vertex is already exist if (new_vertex == V[j]) { flag = true; break; } } if (!flag) { new_vertex.e[1].push_back(E.size()); //add the current edge as incoming new_edge.v[1] = V.size(); //add the new vertex to the edge V.push_back(new_vertex); //add the new vertex to the vertex list id2vert.push_back(i[1]); //add the ID to the ID->vertex conversion list } else { V[j].e[1].push_back(E.size()); new_edge.v[1] = j; } } else{ //if the vertex already exists it_idx = std::distance(id2vert.begin(), it); V[it_idx].e[1].push_back(E.size()); //add the current edge as incoming new_edge.v[1] = it_idx; } E.push_back(new_edge); //push the edge to the list } // copy the radii information from OBJ /*if (O.numVT()) { unsigned k = 0; for (unsigned i = 0; i < E.size(); i++) { for (unsigned j = 0; j < E[i].size(); j++) { E[i].cylinder::set_r(j, O.getVT(k)[0] / 2); k++; } } }*/ // OBJ class assumes that in L the two values are equal if (O.numVT()) { std::vector< unsigned > id; //create an array to store the centerline point IDs for (unsigned i = 0; i < O.numL(); i++) { id.clear(); O.getLinei(i + 1, id); //get the list of point IDs for the line for (unsigned j = 0; j < id.size(); j++) E[i].cylinder::set_r(j, O.getVT(id[j] - 1)[0] / 2); } } } ///loads a .nwt file. Reads the header and loads the data into the network according to the header. void loadNwt(std::string filename) { int dims[2]; ///number of vertex, number of edges readHeader(filename, &dims[0]); //read header std::ifstream file; file.open(filename.c_str(), std::ios::in | std::ios::binary); ///skip header information. file.seekg(14+58+4+4, file.beg); vertex v; for(int i = 0; i < dims[0]; i++) ///for every vertex, read vertex, add to network. { file >> v; V.push_back(v); // std::cout << i << " " << v.str() << std::endl; } std::cout << std::endl; for(int i = 0; i < dims[1]; i++) ///for every edge, read edge, add to network. { edge e; file >> e; E.push_back(e); //std::cout << i << " " << E[i].str() << std::endl; // not necessary? } file.close(); } ///saves a .nwt file. Writes the header in raw text format, then saves the network as a binary file. void saveNwt(std::string filename) { writeHeader(filename); std::ofstream file; file.open(filename.c_str(), std::ios::out | std::ios::binary | std::ios::app); ///since we have written the header we are not appending. for(int i = 0; i < V.size(); i++) ///look through the Vertices and write each one. { // std::cout << i << " " << V[i].str() << std::endl; file << V[i]; } for(int i = 0; i < E.size(); i++) ///loop through the Edges and write each one. { //std::cout << i << " " << E[i].str() << std::endl; // not necesarry? file << E[i]; } file.close(); } ///Writes the header information to a .nwt file. void writeHeader(std::string filename) { std::string magicString = "nwtFileFormat "; ///identifier for the file. std::string desc = "fileid(14B), desc(58B), #vertices(4B), #edges(4B): bindata"; int hNumVertices = V.size(); ///int byte header storing the number of vertices in the file int hNumEdges = E.size(); ///int byte header storing the number of edges. std::ofstream file; file.open(filename.c_str(), std::ios::out | std::ios::binary); std::cout << hNumVertices << " " << hNumEdges << std::endl; file.write(reinterpret_cast(&magicString.c_str()[0]), 14); //write the file id file.write(reinterpret_cast(&desc.c_str()[0]), 58); //write the description file.write(reinterpret_cast(&hNumVertices), sizeof(int)); //write #vert. file.write(reinterpret_cast(&hNumEdges), sizeof(int)); //write #edges // file << magicString.c_str() << desc.c_str() << hNumVertices << hNumEdges; file.close(); } ///Reads the header information from a .nwt file. void readHeader(std::string filename, int *dims) { char magicString[14]; ///id char desc[58]; ///description int hNumVertices; ///#vert int hNumEdges; ///#edges std::ifstream file; ////create stream file.open(filename.c_str(), std::ios::in | std::ios::binary); file.read(reinterpret_cast(&magicString[0]), 14); ///read the file id. file.read(reinterpret_cast(&desc[0]), 58); ///read the description file.read(reinterpret_cast(&hNumVertices), sizeof(int)); ///read the number of vertices file.read(reinterpret_cast(&hNumEdges), sizeof(int)); ///read the number of edges // std::cout << magicString << desc << hNumVertices << " " << hNumEdges << std::endl; file.close(); ///close the file. dims[0] = hNumVertices; ///fill the returned reference. dims[1] = hNumEdges; } //load a network from an SWC file void load_swc(std::string filename) { stim::swc S; // create swc variable S.load(filename); // load the node information S.create_tree(); // link those node according to their linking relationships as a tree S.resample(); //NT.push_back(S.node[0].type); // set the neuronal_type value to the first vertex in the network std::vector id2vert; // this list stores the SWC vertex ID associated with each network vertex unsigned i[2]; // temporary, IDs associated with the first and last points for (unsigned int l = 0; l < S.numE(); l++) { // for every edge //NT.push_back(S.node[l].type); std::vector< stim::vec3 > c; S.get_points(l, c); stim::centerline c3(c.size()); // new fiber for (unsigned j = 0; j < c.size(); j++) c3[j] = c[j]; // copy the points c3.update(); // update the L information stim::cylinder C3(c3); // create a new cylinder in order to copy the origin radius information // upadate the R information std::vector radius; S.get_radius(l, radius); C3.copy_r(radius); edge new_edge(C3); // new edge //create an edge from the given centerline unsigned int I = (unsigned)new_edge.size(); //calculate the number of points on the centerline //get the first and last vertex IDs for the line i[0] = S.E[l].front(); i[1] = S.E[l].back(); std::vector::iterator it; //create an iterator for searching the id2vert array unsigned it_idx; //create an integer for the id2vert entry index //find out if the nodes for this fiber have already been created it = find(id2vert.begin(), id2vert.end(), i[0]); //look for the first node if (it == id2vert.end()) { //if i[0] hasn't already been used vertex new_vertex = new_edge[0]; //create a new vertex, assign it a position new_vertex.e[0].push_back(E.size()); //add the current edge as outgoing new_edge.v[0] = V.size(); //add the new edge to the edge V.push_back(new_vertex); //add the new vertex to the vertex list id2vert.push_back(i[0]); //add the ID to the ID->vertex conversion list } else { //if the vertex already exists it_idx = std::distance(id2vert.begin(), it); V[it_idx].e[0].push_back(E.size()); //add the current edge as outgoing new_edge.v[0] = it_idx; } it = find(id2vert.begin(), id2vert.end(), i[1]); //look for the second ID if (it == id2vert.end()) { //if i[1] hasn't already been used vertex new_vertex = new_edge[I - 1]; //create a new vertex, assign it a position new_vertex.e[1].push_back(E.size()); //add the current edge as incoming new_edge.v[1] = V.size(); //add the new vertex to the edge V.push_back(new_vertex); //add the new vertex to the vertex list id2vert.push_back(i[1]); //add the ID to the ID->vertex conversion list } else { //if the vertex already exists it_idx = std::distance(id2vert.begin(), it); V[it_idx].e[1].push_back(E.size()); //add the current edge as incoming new_edge.v[1] = it_idx; } E.push_back(new_edge); //push the edge to the list } } /// Get adjacency matrix of the network std::vector< typename std::vector > get_adj_mat() { unsigned n = V.size(); // get the number of vertices in the networks std::vector< typename std::vector > result(n, std::vector(n, 0)); // initialize every entry in the matrix to be 0 result.resize(n); // resize rows for (unsigned i = 0; i < n; i++) result[i].resize(n); // resize columns for (unsigned i = 0; i < n; i++) { // for every vertex unsigned num_out = V[i].e[0].size(); // number of outgoing edges of current vertex if (num_out != 0) { for (unsigned j = 0; j < num_out; j++) { int edge_idx = V[i].e[0][j]; // get the jth out-going edge index of current vertex int vertex_idx = E[edge_idx].v[1]; // get the ending vertex of specific out-going edge result[i][vertex_idx] = 1; // can simply set to 1 if it is simple-graph result[vertex_idx][i] = 1; // symmetric } } } return result; } /// Output the network as a string std::string str(){ std::stringstream ss; ss<<"Nodes ("< resample(T spacing){ stim::network n; //create a new network that will be an exact copy, with resampled fibers n.V = V; //copy all vertices //n.NT = NT; //copy all the neuronal type information n.E.resize(edges()); //allocate space for the edge list //copy all fibers, resampling them in the process for(unsigned e = 0; e < edges(); e++){ //for each edge in the edge list n.E[e] = E[e].resample(spacing); //resample the edge and copy it to the new network } return n; //return the resampled network } /// Calculate the total number of points on all edges. unsigned total_points(){ unsigned n = 0; for(unsigned e = 0; e < E.size(); e++) n += E[e].size(); return n; } //Copy the point cloud representing the centerline for the network into an array void centerline_cloud(T* dst) { size_t p; //stores the current edge point size_t P; //stores the number of points in an edge size_t i = 0; //index into the output array of points for (size_t e = 0; e < E.size(); e++) { //for each edge in the network P = E[e].size(); //get the number of points in this edge for (p = 0; p < P; p++) { dst[i * 3 + 0] = E[e][p][0]; dst[i * 3 + 1] = E[e][p][1]; dst[i * 3 + 2] = E[e][p][2]; i++; } } } // convert vec3 to array void stim2array(float *a, stim::vec3 b){ a[0] = b[0]; a[1] = b[1]; a[2] = b[2]; } // convert vec3 to array in bunch void edge2array(T* a, edge b){ size_t n = b.size(); for(size_t i = 0; i < n; i++){ a[i * 3 + 0] = b[i][0]; a[i * 3 + 1] = b[i][1]; a[i * 3 + 2] = b[i][2]; } } // get list of metric std::vector metric() { std::vector result; T m; for (size_t e = 0; e < E.size(); e++) { for (size_t p = 0; p < E[e].size(); p++) { m = E[e].r(p); result.push_back(m); } } return result; } /// Calculate the average magnitude across the entire network. /// @param m is the magnitude value to use. The default is 0 (usually radius). T average(unsigned m = 0){ T M, L; //allocate space for the total magnitude and length M = L = 0; //initialize both the initial magnitude and length to zero for(unsigned e = 0; e < E.size(); e++){ //for each edge in the network M += E[e].integrate(); //get the integrated magnitude L += E[e].length(); //get the edge length } return M / L; //return the average magnitude } /// This function compares two networks and returns the percentage of the current network that is missing from A. /// @param A is the network to compare to - the field is generated for A /// @param sigma is the user-defined tolerance value - smaller values provide a stricter comparison stim::network compare(stim::network A, float sigma, int device = -1){ stim::network R; //generate a network storing the result of the comparison R = (*this); //initialize the result with the current network T *c; // centerline (array of double pointers) - points on kdtree must be double size_t n_data = A.total_points(); // set the number of points c = (T*) malloc(sizeof(T) * n_data * 3); // allocate an array to store all points in the data set unsigned t = 0; for(unsigned e = 0; e < A.E.size(); e++){ //for each edge in the network for(unsigned p = 0; p < A.E[e].size(); p++){ //for each point in the edge for(unsigned d = 0; d < 3; d++){ //for each coordinate c[t * 3 + d] = A.E[e][p][d]; //copy the point into the array c } t++; } } //generate a KD-tree for network A size_t MaxTreeLevels = 3; // max tree level #ifdef __CUDACC__ cudaSetDevice(device); int current_device; if (cudaGetDevice(¤t_device) == device) { std::cout << "Using CUDA device " << device << " for calculations..." << std::endl; } stim::kdtree kdt; // initialize a pointer to a kd tree kdt.create(c, n_data, MaxTreeLevels); // build a KD tree for(unsigned e = 0; e < R.E.size(); e++){ //for each edge in A //R.E[e].add_mag(0); //add a new magnitude for the metric //size_t errormag_id = R.E[e].nmags() - 1; //get the id for the new magnitude size_t n = R.E[e].size(); // the number of points in current edge T* queryPt = new T[3 * n]; T* m1 = new T[n]; T* dists = new T[n]; size_t* nnIdx = new size_t[n]; T* d_dists; T* d_m1; cudaMalloc((void**)&d_dists, n * sizeof(T)); cudaMalloc((void**)&d_m1, n * sizeof(T)); edge2array(queryPt, R.E[e]); kdt.search(queryPt, n, nnIdx, dists); cudaMemcpy(d_dists, dists, n * sizeof(T), cudaMemcpyHostToDevice); // copy dists from host to device // configuration parameters size_t threads = (1024>n)?n:1024; size_t blocks = n/threads + (n%threads)?1:0; find_metric_parallel<<>>(d_m1, n, d_dists, sigma); //calculate the metric value based on the distance cudaMemcpy(m1, d_m1, n * sizeof(T), cudaMemcpyDeviceToHost); for(unsigned p = 0; p < n; p++){ R.E[e].set_r(p, m1[p]); } //d_set_mag<<>>(R.E[e].M, errormag_id, n, m1); } #else stim::kdtree kdt; kdt.create(c, n_data, MaxTreeLevels); for(unsigned e = 0; e < R.E.size(); e++){ //for each edge in A size_t n = R.E[e].size(); // the number of points in current edge T* query = new T[3 * n]; T* m1 = new T[n]; T* dists = new T[n]; size_t* nnIdx = new size_t[n]; edge2array(query, R.E[e]); kdt.cpu_search(query, n, nnIdx, dists); //find the distance between A and the current network for(unsigned p = 0; p < R.E[e].size(); p++){ m1[p] = 1.0f - gaussianFunction((T)dists[p], sigma); //calculate the metric value based on the distance R.E[e].set_r(p, m1[p]); //set the error for the second point in the segment } } #endif return R; //return the resulting network } /// This function compares two networks and split the current one according to the nearest neighbor of each point in each edge /// @param A is the network to split /// @param B is the corresponding mapping network /// @param sigma is the user-defined tolerance value - smaller values provide a stricter comparison /// @param device is the device that user want to use void split(stim::network A, stim::network B, float sigma, int device, float threshold){ T *c; size_t n_data = B.total_points(); c = (T*) malloc(sizeof(T) * n_data * 3); size_t NB = B.E.size(); // the number of edges in B unsigned t = 0; for(unsigned e = 0; e < NB; e++){ // for every edge in B for(unsigned p = 0; p < B.E[e].size(); p++){ // for every points in B.E[e] for(unsigned d = 0; d < 3; d++){ c[t * 3 + d] = B.E[e][p][d]; // convert to array } t++; } } size_t MaxTreeLevels = 3; // max tree level #ifdef __CUDACC__ cudaSetDevice(device); stim::kdtree kdt; // initialize a pointer to a kd tree //compare each point in the current network to the field produced by A kdt.create(c, n_data, MaxTreeLevels); // build a KD tree std::vector > relation; // the relationship between GT and T corresponding to NN relation.resize(A.E.size()); for(unsigned e = 0; e < A.E.size(); e++){ //for each edge in A //A.E[e].add_mag(0); //add a new magnitude for the metric //size_t errormag_id = A.E[e].nmags() - 1; size_t n = A.E[e].size(); // the number of edges in A T* queryPt = new T[3 * n]; // set of all the points in current edge T* m1 = new T[n]; // array of metrics for every point in current edge T* dists = new T[n]; // store the distances for every point in current edge size_t* nnIdx = new size_t[n]; // store the indices for every point in current edge // define pointers in device T* d_dists; T* d_m1; size_t* d_nnIdx; // allocate memory for defined pointers cudaMalloc((void**)&d_dists, n * sizeof(T)); cudaMalloc((void**)&d_m1, n * sizeof(T)); cudaMalloc((void**)&d_nnIdx, n * sizeof(size_t)); edge2array(queryPt, A.E[e]); // convert edge to array kdt.search(queryPt, n, nnIdx, dists); // search the tree to find the NN for every point in current edge cudaMemcpy(d_dists, dists, n * sizeof(T), cudaMemcpyHostToDevice); // copy dists from host to device cudaMemcpy(d_nnIdx, nnIdx, n * sizeof(size_t), cudaMemcpyHostToDevice); // copy Idx from host to device // configuration parameters size_t threads = (1024>n)?n:1024; // test to see whether the number of point in current edge is more than 1024 size_t blocks = n/threads + (n%threads)?1:0; find_metric_parallel<<>>(d_m1, n, d_dists, sigma); // calculate the metrics in parallel cudaMemcpy(m1, d_m1, n * sizeof(T), cudaMemcpyDeviceToHost); for(unsigned p = 0; p < n; p++){ A.E[e].set_r(p, m1[p]); // set the error(radius) value to every point in current edge } relation[e].resize(n); // resize every edge relation size unsigned* d_relation; cudaMalloc((void**)&d_relation, n * sizeof(unsigned)); // allocate memory std::vector edge_point_num(NB); // %th element is the number of points that %th edge has for(unsigned ee = 0; ee < NB; ee++) edge_point_num[ee] = B.E[ee].size(); size_t* d_edge_point_num; cudaMalloc((void**)&d_edge_point_num, NB * sizeof(size_t)); cudaMemcpy(d_edge_point_num, &edge_point_num[0], NB * sizeof(size_t), cudaMemcpyHostToDevice); find_edge_index_parallel<<>>(d_nnIdx, n, d_relation, d_edge_point_num, NB); // find the edge corresponding to the array index in parallel cudaMemcpy(&relation[e][0], d_relation, n * sizeof(unsigned), cudaMemcpyDeviceToHost); //copy relationship from device to host } #else stim::kdtree kdt; kdt.create(c, n_data, MaxTreeLevels); std::vector> relation; // the mapping relationship between two networks relation.resize(A.E.size()); for(unsigned i = 0; i < A.E.size(); i++) relation[i].resize(A.E[i].size()); std::vector edge_point_num(NB); //%th element is the number of points that %th edge has for(unsigned ee = 0; ee < NB; ee++) edge_point_num[ee] = B.E[ee].size(); for(unsigned e = 0; e < A.E.size(); e++){ //for each edge in A size_t n = A.E[e].size(); //the number of edges in A T* queryPt = new T[3 * n]; T* m1 = new T[n]; T* dists = new T[n]; //store the distances size_t* nnIdx = new size_t[n]; //store the indices edge2array(queryPt, A.E[e]); kdt.search(queryPt, n, nnIdx, dists); for(unsigned p = 0; p < A.E[e].size(); p++){ m1[p] = 1.0f - gaussianFunction((T)dists[p], sigma); //calculate the metric value based on the distance A.E[e].set_r(p, m1[p]); //set the error for the second point in the segment unsigned id = 0; //mapping edge's idx size_t num = 0; //total number of points before #th edge for(unsigned i = 0; i < NB; i++){ num += B.E[i].size(); if(nnIdx[p] < num){ //find the edge it belongs to relation[e][p] = id; break; } id++; //current edge won't be the one, move to next edge } } } #endif E = A.E; V = A.V; unsigned int id = 0; // split value for(unsigned e = 0; e < E.size(); e++){ // for every edge for(unsigned p = 0; p < E[e].size() - 1; p++){ // for every point in each edge int t = (int)(E[e].length() / sigma * 2); if (t <= 20) threshold_fac = E[e].size(); else threshold_fac = (E[e].length() / sigma * 2)/10; if(relation[e][p] != relation[e][p + 1]){ // find the nearest edge changing point id = p + 1; // if there is no change in NN if(id < threshold_fac || (E[e].size() - id) < threshold_fac) id = E[e].size() - 1; // extreme situation is not acceptable else break; } if(p == E[e].size() - 2) // if there is no splitting index, set the id to the last point index of current edge id = E[e].size() - 1; } //unsigned errormag_id = E[e].nmags() - 1; T G = 0; // test to see whether it has its nearest neighbor for(unsigned i = 0; i < E[e].size(); i++) G += E[e].r(i); // won't split special edges if(G / E[e].size() > threshold) // should based on the color map id = E[e].size() - 1; // set split idx to outgoing direction vertex std::vector tmpe; tmpe.resize(2); tmpe = E[e].split(id); vertex tmpv = stim::vec3(-1, -1, 0); // store the split point as vertex if(tmpe.size() == 2){ relation.resize(relation.size() + 1); for(unsigned d = id; d < E[e].size(); d++) relation[relation.size() - 1].push_back(relation[e][d]); tmpe[0].v[0] = E[e].v[0]; // begining vertex of first half edge -> original begining vertex tmpe[1].v[1] = E[e].v[1]; // ending vertex of second half edge -> original ending vertex tmpv = E[e][id]; V.push_back(tmpv); tmpe[0].v[1] = (unsigned)V.size() - 1; // ending vertex of first half edge -> new vertex tmpe[1].v[0] = (unsigned)V.size() - 1; // begining vertex of second half edge -> new vertex edge tmp(E[e]); E[e] = tmpe[0]; // replace original edge by first half edge E.push_back(tmpe[1]); // push second half edge to the last V[V.size() - 1].e[1].push_back(e); // push first half edge to the incoming of new vertex V[V.size() - 1].e[0].push_back((unsigned)E.size() - 1); // push second half edge to the outgoing of new vertex for(unsigned i = 0; i < V[tmp.v[1]].e[1].size(); i++) // find the incoming edge of original ending vertex if(V[tmp.v[1]].e[1][i] == e) V[tmp.v[1]].e[1][i] = (unsigned)E.size() - 1; // set to new edge } } } /// This function compares two splitted networks and yields a mapping relationship between them according to NN /// @param B is the network that the current network is going to map to /// @param C is the mapping relationship: C[e1] = _e1 means e1 edge in current network is mapping the _e1 edge in B /// @param device is the device that user want to use void mapping(stim::network B, std::vector &C, int device, float threshold){ stim::network A; //generate a network storing the result of the comparison A = (*this); size_t n = A.E.size(); // the number of edges in A size_t NB = B.E.size(); // the number of edges in B C.resize(A.E.size()); T *c; // centerline (array of double pointers) - points on kdtree must be double size_t n_data = B.total_points(); // set the number of points c = (T*) malloc(sizeof(T) * n_data * 3); unsigned t = 0; for(unsigned e = 0; e < NB; e++){ // for each edge in the network for(unsigned p = 0; p < B.E[e].size(); p++){ // for each point in the edge for(unsigned d = 0; d < 3; d++){ // for each coordinate c[t * 3 + d] = B.E[e][p][d]; } t++; } } //generate a KD-tree for network A //float metric = 0.0; // initialize metric to be returned after comparing the network size_t MaxTreeLevels = 3; // max tree level #ifdef __CUDACC__ cudaSetDevice(device); stim::kdtree kdt; // initialize a pointer to a kd tree kdt.create(c, n_data, MaxTreeLevels); // build a KD tree for(unsigned e = 0; e < n; e++){ //for each edge in A //size_t errormag_id = A.E[e].nmags() - 1; //get the id for the new magnitude //pre-judge to get rid of impossibly mapping edges T M = 0; for(unsigned p = 0; p < A.E[e].size(); p++) M += A.E[e].r(p); M = M / A.E[e].size(); if(M > threshold) C[e] = (unsigned)-1; //set the nearest edge of impossibly mapping edges to maximum of unsigned else{ T* queryPt = new T[3]; T* dists = new T[1]; size_t* nnIdx = new size_t[1]; stim2array(queryPt, A.E[e][A.E[e].size()/2]); kdt.search(queryPt, 1, nnIdx, dists); unsigned id = 0; //mapping edge's idx size_t num = 0; //total number of points before #th edge for(unsigned i = 0; i < NB; i++){ num += B.E[i].size(); if(nnIdx[0] < num){ C[e] = id; break; } id++; } } } #else stim::kdtree kdt; kdt.create(c, n_data, MaxTreeLevels); T *dists = new T[1]; // near neighbor distances size_t *nnIdx = new size_t[1]; // near neighbor indices // allocate near neigh indices stim::vec3 p0, p1; T* queryPt = new T[3]; for(unsigned int e = 0; e < R.E.size(); e++){ // for each edge in A T M; // the sum of metrics of current edge for(unsigned p = 0; p < R.E[e].size(); p++) M += A.E[e].r(p); M = M / A.E[e].size(); if(M > threshold) C[e] = (unsigned)-1; else{ // if it should have corresponding edge in B, then... p1 = R.E[e][R.E[e].size()/2]; stim2array(queryPt, p1); kdt.cpu_search(queryPt, 1, nnIdx, dists); // search the tree unsigned id = 0; //mapping edge's idx size_t num = 0; //total number of points before #th edge for(unsigned i = 0; i < NB; i++){ num += B.E[i].size(); if(nnIdx[0] < num){ C[e] = id; break; } id++; } } } #endif } /// Returns the number of magnitude values stored in each edge. This should be uniform across the network. //unsigned nmags(){ // return E[0].nmags(); //} // split a string in text by the character sep stim::vec split(std::string &text, char sep) { stim::vec tokens; std::size_t start = 0, end = 0; while ((end = text.find(sep, start)) != std::string::npos) { tokens.push_back(atof(text.substr(start, end - start).c_str())); start = end + 1; } tokens.push_back(atof(text.substr(start).c_str())); return tokens; } // load a network in text file to a network class void load_txt(std::string filename) { std::vector file_contents; std::ifstream file(filename.c_str()); std::string line; std::vector id2vert; //this list stores the vertex ID associated with each network vertex //for each line in the text file, store them as strings in file_contents while (std::getline(file, line)) { std::stringstream ss(line); file_contents.push_back(ss.str()); } unsigned int numEdges = atoi(file_contents[0].c_str()); //number of edges in the network unsigned int I = atoi(file_contents[1].c_str()) ; //calculate the number of points3d on the first edge unsigned int count = 1; unsigned int k = 2; // count is global counter through the file contents, k is for the vertices on the edges // for each edge in the network. for (unsigned int i = 0; i < numEdges; i ++ ) { // pre allocate a position vector p with number of points3d on the edge p std::vector< stim::vec > p(0, I); // for each point on the nth edge for (unsigned int j = k; j < I + k; j++) { // split the points3d of floats with separator space and form a float3 position vector out of them p.push_back(split(file_contents[j], ' ')); } count += p.size() + 1; // increment count to point at the next edge in the network I = atoi(file_contents[count].c_str()); // read in the points3d at the next edge and convert it to an integer k = count + 1; edge new_edge = p; // create an edge with a vector of points3d on the edge E.push_back(new_edge); // push the edge into the network } unsigned int numVertices = atoi(file_contents[count].c_str()); // this line in the text file gives the number of distinct vertices count = count + 1; // this line of text file gives the first verrtex // push each vertex into V for (unsigned int i = 0; i < numVertices; i ++) { vertex new_vertex = split(file_contents[count], ' '); V.push_back(new_vertex); count += atoi(file_contents[count + 1].c_str()) + 2; // Skip number of edge ids + 2 to point to the next vertex } } // end load_txt function // strTxt returns a string of edges std::string strTxt(std::vector< stim::vec > p) { std::stringstream ss; std::stringstream oss; for(unsigned int i = 0; i < p.size(); i++){ ss.str(std::string()); for(unsigned int d = 0; d < 3; d++){ ss<